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. 2022 May 9;23(9):5259. doi: 10.3390/ijms23095259

Figure 1.

Figure 1

Farnesoid X receptor (FXR) expression and the effects on cell viability in human bladder cancers. (A,B) Overall and disease-free survival rate in differential expression of NR1H4 (FXR) gene in TCGA database of bladder cancer patients. (C) Scatter plots in differential expression of FXR gene in TCGA database of bladder cancer tissues (red plot) and adjacent normal tissues (blue plot). * p < 0.05 compared with the bladder cancer tissues group. (D) The expression levels of FXR and SHP in the bladder cancer cell lines were analyzed by Western blotting. GAPDH was a loading control. * p < 0.05 compared with the T24 group. (E) The survival rate of TSGH8301 and T24 were analyzed after doxycycline induced for 72 h in vector control and FXR overexpressed groups using MTT assay. (F) Colony formation assay of TSGH8301 and T24 were analyzed after 9 days of doxycycline induction in vector control and FXR overexpressed groups. Wells were visualized and quantified. ** p < 0.01; *** p < 0.001 compared with the control group.