Table 2.

Multivariate predictors of chemotherapy and radiation toxicity breaks. * Selected variable identified by random forest method. Bolded variables represent p-value < 0.05.

	Chemotherapy Toxicity		Any Radiation Break		Prolonged Radiation Breaks
	Odds Ratio (95% CI)	p-Value	Odds Ratio (95% CI)	p-Value	Odds Ratio (95% CI)	p-Value
Age ≥ 70	2.76 (1.36–5.60)	<0.01	2.23 (1.19–4.19)	0.012 *	3.21 (1.37–7.51)	<0.01
ECOG Performance status				0.11
0–1			0.50 (0.22–1.18)
≥2			Ref
Smoking Status		<0.01
Never	Ref
Former	0.61 (0.32–1.15)
Current	2.32 (1.11–4.89)
BMI						0.18
<30					0.47 (0.16–1.42)
≥30					Ref
Low SMI		<0.01 *				0.044 *
Yes	2.14 (1.25–3.66)				2.70 (1.03–7.11)
No	Ref				Ref
SMG				0.06		0.24
High			Ref		Ref
Low			1.67 (0.97–2.88)		1.71 (0.70–4.19)
Pre-treatment albumin						0.033 *
>3.5 g/dL					Ref
≤3.5 g/dL					2.83 (1.09–7.37)