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. 2022 Apr 28;14(9):2207. doi: 10.3390/cancers14092207

Figure 2.

Figure 2

BTP-7 conjugation enhances drug solubility. (a) BTP-7 (and Scr-7) conjugation to CPT enhances drug solubility at 0.1 mM (low conc.) and (b) 1.3 mM (high conc.). CPT, CPT-11, BTP-7-CPT, and Scr-7-CPT stocks (in DMSO) were diluted in either DMSO or saline. Samples were centrifuged to pellet insoluble compound, and the resulting supernatant was analyzed by LC-MS. Solubility is measured by comparing the extracted ion chromatogram of the sample diluted in saline vs. in DMSO. Statistical significance was determined using a two-way ANOVA and Tukey’s multiple comparisons test (ns: non-significant, ** p < 0.01, *** p < 0.001, **** p < 0.0001).