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. 2022 Apr 28;14(9):2207. doi: 10.3390/cancers14092207

Figure 5.

Figure 5

Stability of peptide–drug conjugates in serum. (a,b) LC-MS analysis showing the level of (a) BTP-7-CPT and (b) Scr-7-CPT detected (extracted ion count) in PBS and in 25% human serum over 12 h (n = 3). (c) Schematics of BTP-7 conjugated to an aminohexanoic acid linker (X) at the C-terminus (BTP-7-X), BTP-7-X functionalized with a cysteine (Cys) residue at the C-terminus (BTP-7-X-Cys), and BTP-7-CPT drug conjugate. (d) Stability of compounds from (c) in 25% human serum. All datasets were normalized to the EIC at t = 0 (n = 2).