Table 1.

Examples of bioactive peptides and proteins cleaved by DPP-IV [2,3,4,5,6].

Chemokines	CXCL12 (SDF-1), CXCL11 (I-TAC), CXCL10 (IP-10), CXCL9 (Mig), CCL11 (eotaxin), CCL5 (RANTES), CCL3L1, CCL22 (MDC)
Incretins	GLP-1, GIP
Neuropeptides	SP, PYY, NPY, VIP, PACAP
Other	GLP-2, BNP, erythropoietin, GHRH, GRP, glucagon, procalcitonin

BNP = Brain natriuretic peptide; GHRH = Growth-hormone-releasing hormone; GIP = Glucose-dependent insulinotropic polypeptide; GLP = Glucagon-like peptide; GRP = Gastrin-releasing peptide; IP-10 = Interferon-gamma-induced protein 10; I-TAC = Interferon-inducible T-cell alpha chemoattractant; MDC = Macrophage-derived chemokine; Mig = Monokine induced by gamma interferon; NPY = Neuropeptide Y; PACAP = Pituitary adenylate cyclase-activating polypeptide; PYY = Peptide YY; RANTES = Regulated on activation, normal T cell expressed and secreted; SDF-1 = Stromal-cell-derived factor 1; SP = Substance P; VIP = Vasoactive intestinal peptide.