Table 3.
Summary of preclinical studies demonstrating possible chemopreventive effects of gliptins.
| Tumor Type | Model | Gliptin | Reference |
|---|---|---|---|
| Hepatocellular carcinoma | Diethylnitrosamine + high-fat diet-induced carcinogenesis in rats | Vildagliptin | [112] |
| Thiacetamide-induced carcinogenesis in rats | Saxagliptin | [117] | |
| Hepatocellular carcinoma associated with nonalcoholic steatohepatitis | Melanocortin 4 receptor (MC4R)-deficient mice fed Western-type diet | Anagliptin | [119] |
| STAM mouse model | Sitagliptin | [120] | |
| Choline deficiency-induced steatohepatitis in rats | Teneligliptin | [121] | |
| Choline deficiency-induced steatohepatitis in rats | Sitagliptin | [122] | |
| Colorectal cancer | 1,2-dimethylhydrazine and high-fat diet in rats | Sitagliptin | [129] |
| Leptin-deficient mice administered 1,2-dimethylhydrazine and dextran sulfate sodium-induced colitis | Sitagliptin | [130] | |
| Mice with heterozygous Apc mutation fed high-fat diet | Sitagliptin | [131] | |
| Renal cell carcinoma | Diethylnitrosamine-induced carcinogenesis in rats | Sitagliptin | [132] |