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. 2022 May 6;23(9):5209. doi: 10.3390/ijms23095209

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Hypoxia alleviates fatty liver and alters the expression of fatty liver markers. (A) Livers were isolated from indicated groups of mice and weighed (mean ± SEM, n = 8). *** p < 0.005. (B) Representative images of gross liver, H&E (10×), and Oil Red O staining (20×) are presented. (C–E) Liver extracts were blotted with antibodies against UCP1 and FASN. Bands were quantified by ImageJ and normalized by GAPDH. (F,G) Expression of selected genes for (F) lipid metabolism, mitogenesis, and thermogenesis, and (G) M2 markers for macrophages in the liver were examined by qPCR, and the signals were normalized by 18S rRNA. Significance was tested by Student’s t-test (mean ± SEM, n = 3), * p < 0.05.