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. 2022 Apr 29;23(9):4945. doi: 10.3390/ijms23094945

Figure 2.

Figure 2

Stressed mice exhibit increased anxiety-like behavior in the OFT. Male and female stressed mice present higher levels of anxiety at the age of two ((A), F (1, 46) = 56.24, p < 0.0001) and four months ((B), F (1, 43) = 16.55, p = 0.0002), which manifested in spending significantly less time in the center of the OF compared to naïve mice At the age of six months, no significant differences were found between stressed and naïve mice (A) Male 2M n(naïve) = 10, n(UCMS) = 17. Female 2M, n(naïve) = 9, n(UCMS) = 14) (B) Male 4M t(df = 23) = 2.92, n(naïve) = 9, n(UCMS) = 16. Female 4M n(naïve) = 6, n(UCMS) = 16). (C) Male 6M n(naïve) = 9, n(UCMS) = 12. Female 6M n(naïve) = 6, n(UCMS) = 9). Data are presented as mean ± SEM and scatter dot plot. *** indicates p < 0.0002.