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. 2022 Apr 26;23(9):4764. doi: 10.3390/ijms23094764

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Main findings regarding the alterations of ECS components in animal models and patients with depression. 2-AG: 2-arachidonoylglycerol; ACC: anterior cingulate cortex; AEA: anandamide; CB1r: cannabinoid receptor 1; CNR1: gene encoding CB1r; FAAH: gene encoding fatty acid amide hydrolase; FSL: Flinders Sensitive Line rats; HIPP: hippocampus; HYP: hypothalamus; MDD: major depressive disorder; MGLL: gene encoding MAGL; NAcc: nucleus accumbens; PFC: prefrontal cortex; SSRI: selective serotonin reuptake inhibitors; ST: striatum; WKY: Wistar Kyoto rats.