Table 4.

Summary of the main findings regarding the alterations of ECS components in animals and human studies in Cocaine Use Disorders.

Cocaine Use Disorders
References	Type of Sample	Type of Evaluation	Outcomes
[462]	Human	Post-mortem	↓ CB1r and GRK2/3/5 in the PFC in CoUDs
[463]	Animals	CB1r KO vs WT mice	25% of the CB1r KO mice compared to the 75% of their WT littermates acquired a reliable operant responding to self-administration of cocaine, and the number of sessions required to attain this behavior was ↑ in CB1r KO mice.
[464]	Animals	Glu-CB1r vs GABA-CB1r KO vs WT	CB1r expression in forebrain GABAergic neurons-controlled sensitivity to cocaine, while CB1r expression in cortical glutamatergic neurons controlled the associative learning processes.
[465]	Animals	D1-CNR1 KO vs A2a-CNR1 KO vs WT mice	D1-CNR1 KO mice did not display hyperlocomotion in response to acute cocaine dosing. D1-CNR1 and A2a-CNR1 KO mice exhibited blunted locomotor activity across repeated cocaine doses A2a-CNR1 KO mice did not express a preference for cocaine paired environments in a two-choice place preference task.
[466]	Animals	Male Long Evans rats	Systemic cocaine increased premature responding, a measure of impulsivity.
[467]	Animals	Transgenic mice overexpressing the CB2r vs WT littermates	Overexpression of the CB2r significantly ↓ motor response to acute administration of cocaine cocaine-induced motor sensitization, CPP, and cocaine self-administration.
[427]	Animals	DAT-CNR2 KO vs WT mice	DAT-CNR2 KO mice enhanced psychostimulant-induced hyperactivity but an absence of psychostimulant-induced sensitization compared to WT mice.
[468]	Animals	Male Wistar rats	Following cocaine self-administration, a ↑ CB1r expression in the VTA and a ↓ CB1r expression in the PFC, dorsal striatum, and AMY. Cocaine abstinence, ↑CB1r expression in the SN and the AMY, and a ↓ CB2r expression in the PFC, NAcc, and medial globus pallidus.