Table 5.

Summary of main findings regarding the alterations of the ECS components in animals and human studies in Cocaine Use Disorders.

Opiate Use Disorders
Authors	Type of Sample	Type of Evaluation	Outcomes
[469]	Humans	Peripheral Plasma	In morphine abusers, CB2r were upregulated in the PBMCs.
[471]	Animals	CB1r KO vs WT mice	CB1r KO mice, the reinforcing properties of morphine and the severity of the morphine withdrawal syndrome were strongly ↓.
[472]	Animals	CB1r KO vs WT mice	The sensitization to the locomotor response induced by chronic morphine treatment was abolished in CB1r KO mice. Morphine induced a CPP in WT mice but failed to produce any response in CB1r KO mice
[469]	Animals	Sprague-Dawley rats under morphine exposure vs control rats	Rats under morphine exposure exhibited CB2r upregulation in the spleen and PBMCs
[473]	Animals	CBr2 KO vs KO mice	In WT mice, LY2828360 blocked morphine-induced reward in a CPP paradigm, whereas morphine-induced reward was absent in CB2r KO mice. LY2828360 partially attenuated naloxone-precipitated opioid withdrawal in morphine-dependent WT mice, whereas this withdrawal was markedly exacerbated in CB2r KO mice
[474]	Animals	Maternally deprived adolescent rats	Maternally deprived adolescent rats exhibited ↑ AEA in the NAcc, the Cpu nucleus, and the mesencephalon Maternally deprived adult rats, showed ↑ AEA and 2-AG in the NAcc, and ↑ 2-AG in the CPu nucleus,