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. 2022 Apr 30;23(9):4986. doi: 10.3390/ijms23094986

Figure 2.

Figure 2

Caspase-11 non-canonical inflammasome-activated signaling pathways. Activation of caspase-11 non-canonical inflammasome induces the proteolytic processing of GSDMD. The processed N-GSDMD fragments move to the cell membrane and then generate GSDMD pores, leading to pyroptosis. Activation of caspase-11 non-canonical inflammasome also induces NLRP3 canonical inflammasome-mediated proteolytic activation of caspase-1, and the active caspase-1 induces the proteolytic maturation and secretion of IL-1β and IL-18 through GSDMD pores.