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. 2022 May 6;23(9):5197. doi: 10.3390/ijms23095197

Figure 1.

Figure 1

Genetic deletion of Rev-erbα reduces ethanol preference and consumption in male and female mice. Preference for 10% ethanol is (A) reduced in Rev-erb−/− mice relative to Rev-erb+/+ and Rev-erb+/− mice (p < 0.001 ***) and elevated in females compared to males (p < 0.01 §§). Ethanol intake normalized to body mass is also (B) reduced in Rev-erb−/− mice compared to the other groups on most testing days (p < 0.05 *, < 0.01 **, < 0.001 *** vs. Rev-erb+/+, p < 0.05 #, <0.01 ## vs. Rev-erb+/−) and (C) greater in females compared to males according to daily average consumption (p < 0.01 §§). (D) Water consumption normalized to body mass was greater in Rev-erb−/− compared to the Rev-erb+/+ and Rev-erb+/− groups (p < 0.001 ***). Average daily (E) total fluid intake (p < 0.01 §§), (F) food intake (p < 0.05 §), (G) calorie intake (p < 0.01 §§) normalized to body mass was greater in females than males.