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. 2022 May 6;23(9):5197. doi: 10.3390/ijms23095197

Figure 2.

Figure 2

Pharmacological inhibition of REV-ERBα/β with 25 mg/kg (A–C) or 50 mg/kg (D–K) of SR8278 did not alter ethanol preference, ethanol intake, or water intake from the water-only bottle in mice. In male mice, 25 mg/kg of SR8278 did not alter (A) ethanol preference, (B) ethanol intake normalized to body mass, or (C) water intake from the water-only bottle normalized to body mass compared to vehicle treatment. In male and female mice, 50 mg/kg of SR8278 did not alter (D) ethanol preference, (E) ethanol intake normalized to body mass, or (F) water intake from the water-only bottle normalized to body mass compared to vehicle treatment. Irrespective of treatment (50 mg/kg SR8278 or vehicle), there was a (G) trend toward a significant effect of sex on ethanol preference (p = 0.06), with females showing greater average daily (H) ethanol intake (p < 0.01), (I) total fluid intake (p < 0.001), (J) food intake (p < 0.001), and (K) caloric intake (p < 0.001) compared to males when normalized to body mass. p = 0.06 #, p < 0.01 **, p < 0.001 ***. (A–F) Solid lines indicate time of onset of SR8278 injection; dashed lines indicate time of cessation of daily injections.