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. Author manuscript; available in PMC: 2022 May 13.
Published in final edited form as: ACS Chem Biol. 2021 Aug 20;16(9):1628–1643. doi: 10.1021/acschembio.1c00138

Figure 7. Z-Arg-Lys-AOMK and Z-Glu-Lys-AOMK inhibitors of cathepsin B at neutral pH compared to acidic pH conditions.

Figure 7.

(a) Z-Arg-Lys-AOMK inhibitor. Z-Arg-Lys-AOMK inhibition of cathepsin B was assessed at different inhibitor concentrations to determine IC50 values at pH 7.2 and pH 4.6. Z-Phe-Arg-AMC was used as substrate for cathepsin B assays.

(b) Z-Glu-Lys-AOMK inhibitor. The inhibitor Z-Glu-Lys-AOMK at different concentrations was assessed for IC50 values at pH 4.6 and pH 7.2.