Table 1.
Origin of the samples used in reviewed studies.
| Paper | Sample Acquisition | Organoids/No. of Samples | Country |
|---|---|---|---|
| Burgues 2007 [29] | TURB | 31/40 | Spain |
| Fierabracci 2007 [30] | TUR-normal bladder | 6/6 | Italy |
| Bentivegna 2010 [31] | TURB | 29/40 (a) | Italy |
| Hofner 2013 [25] | PDX | 2/2 | Germany |
| Okuyama 2013 [22] | TURB, RC, PDX | 128/152 (b) | Japan |
| Yoshida 2015a [23] | surgical resection | 119/176 (b) | Japan |
| Yoshida 2015b [24] | PDX, resected, urine | NA (b),(c) | Japan |
| Gabig 2016 [26] | TURB | na | USA |
| Gheibi 2017 [32] | PDX, patients | 6 | USA |
| Pauli 2017 [33] | Surgical resection | 8/24 (d) | USA |
| Ooki 2018 [34] | PDX | 2 | USA |
| Lee 2018 [15] | TURB, PDX | 12/18 | USA |
| Yoshida 2018 [35] | TURB | 4 | USA |
| Neal 2018 [27] | surgical resection | NA (e) | USA |
| Kita 2019 [36] | TURB, PDX | 6/15, 2(PDX) | Japan |
| Mullenders 2019 [17] | TURB, RC-normal and tumor | 77/133 (f) | Netherlands |
| Kim 2020 [37] | TURB, RC-normal and tumor | 9 | South Korea |
| Whyard 2020 [19] | TURB | 4 (g) | USA |
| Namekawa 2020 [38] | TURB | 2 | Japan |
| Yoon 2020 [28] | TURB | 2 | South Korea |
| Amaral 2020 [39] | PDX | 2 | USA |
| Murakami 2021 [40] | TURB, PDX | 7 | Japan |
| Yu 2021 [41] | RC | 3 | China |
| Cai 2021 [16] | PDX | 2 (early & late P) | USA |
(a) 50 samples were collected, but only 40 had enough tissue for further processing. (b) Organoids from the same cohort of patients, here considered as one expanded cohort. (c) Missing or unclear information about number of samples. (d) Large cohort of pan-cancer organoids. Bladder and ureter organoids reported together. (e) Large cohort of pan-cancer organoids, at least one from urothelial carcinoma. (f) A total of 133 tissue samples were collected from 53 patients including normal-appearing urothelium and one or more tumor pieces per patient. (g) Two cultures, S2 and S2-1, were derived from the same line. Counted as four primary samples instead of five. TURB: transurethral resection of the bladder; RC: radical cystectomy; PDX: patient-derived xenografts; NA: information not available.