TABLE 1.

Overview of selected fungal peroxins (PEX proteins) important for peroxisome biogenesis and fungal virulence

Name	Function	Description
PEX5, PEX9	PTS1 receptors	PTS1 matrix protein binding and transport to peroxisomes; import pore formation (by PEX5)
PEX7, PEX18, PEX20, PEX21	PTS2 receptor (PEX7) and PTS2 coreceptors (PEX18, 20, 21)	PTS2 matrix protein binding and transport to peroxisomes
PEX13, PEX14, PEX17, PEX33	PEX5 docking and pore formation	Docking complex formation in the peroxisomal membrane; binding of the PEX5–cargo complex; import pore formation for PTS1 proteins (by PEX14 and PEX5) and PTS2 proteins (by PEX14, PEX17, PEX18)
PEX4, PEX22	PEX5 recycling	Monoubiquitination of PEX5 by PEX4 acting as ubiquitin‐conjugating enzyme (E2); PEX4 is membrane‐anchored by PEX22
PEX2, PEX10, PEX12	PEX5 recycling	RING finger‐containing ubiquitin ligase (E3) complex for mono‐ubiquitination of PEX5
PEX1, PEX6, PEX15, PEX26	PEX5 recycling	Formation of a heterohexameric AAA+ ATPase complex by PEX1 and PEX6 that mediates ATP‐dependent extraction of PEX5 from the membrane; the complex is membrane‐anchored by PEX15 or PEX26
PEX8	PTS1 cargo release factor	Dissociation of PTS1 cargo from PEX5 in the matrix
PEX19, PEX3	PMP import	Receptor for PMPs (PEX19), anchored by PEX3 in the peroxisomal membrane

As revealed by the corresponding knockout mutants, PEX proteins in boldface have relevant protein functions in virulence in different fungal species.