Table A1.

Definitions of comorbidities.

Comorbidity	Definition
Hypertension	Prior medical diagnosis of hypertension.
Diabetes	Diabetes Mellitus requiring treatment with insulin or hypoglycemic agents at the time of initiation of conditioning or HbA1c > 7%.
Dyslipidemia	Prior medical diagnosis of dyslipidemia.
Cardiovascular	Coronary artery disease, congestive heart failure, history of myocardial infarction, or left ventricular ejection fraction ≤ 50%., or prior diagnosis of cerebrovascular disease (diagnostic imaging tests is required).
Pulmonary	DLCo1 or FEV1 < 80%. Restrictive Lung Disease or Chronic obstructive pulmonary disease with dyspnea.
Renal	eGFRc < 60 mL/min.
Hepatic	Serum bilirubin ≥ 1.5 times ULN; ALT or AST ≥ 2.5 times ULN, or chronic hepatitis.
HIV	Prior medical diagnosis of HIV by using serological and molecular test.
HBV	Prior medical diagnosis of active HBV infection by using serological and molecular test.
HCV	Prior medical diagnosis of active HCV infection by using serological and molecular test.
Other neoplasm	Malignancy unrelated to the Myelofibrosis which has been treated at any point in the patient’s history, excluding non-melanoma skin cancer
Smoking	Someone who has smoked greater than 100 cigarettes (including hand rolled cigarettes, cigars, cigarillos etc) in their lifetime and has smoked in the last 180 days.

ALT, alanine transaminase; AST, aspartate transaminase; DLCo, diffusion capacity of the lungs for carbon monoxide; FEV1, forced expiratory volume in the first second; eGFR, estimated glomerular filtration rate; HIV, human immunodeficiency virus; HBV, Hepatitis B virus; HCV, Hepatitis C virus; ULN, upper limit of normal.