Table 3.
Drug | pH | Drug Release (mg) Itraconazole |
‘n’ | ‘k’ | Diffusion Coefficient (cm2h−1) | Mechanism | |||
---|---|---|---|---|---|---|---|---|---|
Initial | Final | Di | DA | DL | |||||
Itraconazole | 2 | 0.75 | 9.2 | 0.462 | 1.431 | 0.176 | 0.021 | 0.08 | Fickian |
7 | 1.14 | 14.3 | 1.064 | 1.256 | 0.329 | 0.189 | 0.094 | Non-Fickian | |
9.2 | 0.89 | 11.45 | 0.492 | 1.123 | 0.297 | 0.079 | 0.091 | Fickian |