Table 4.

Kinetic interpretation of different models for the release of itraconazole from CH-Ag bionanocomposite.

Drug	Kinetic Model		pH 2	pH 7	pH 9.2
Itraconazole	Zero order	R2	0.769	0.929	0.842
		k0 (mg h−1)	0.102	0.181	0.135
	First order	R2	0.994	0.999	0.997
		k1 (h−1)	0.163	0.192	0.187
	Higuchi	R2	0.936	0.954	0.949
		k2 (h−1/2)	0.489	0.672	0.598
	Korsmeyer–Peppas	R2	0.967	0.993	0.982
		k3 (h−n)	0.479	0.596	0.501
	Hixson–Crowell	R2	0.714	0.798	0.752
		k4 (h−1/3)	0.132	0.167	0.149