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. 2022 Apr 29;12:838060. doi: 10.3389/fcimb.2022.838060

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Copyright © 2022 Chen, Li, Xie, Chen, Xue, Wang, Ye, Wu, Yang, Zhao, Zhang, Ding and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Limosilactobacillus fermentum XJC60 and nicotinamide (NAM) on ECM and inflammation in UVB-injured HaCaT cells. (A) Evaluation of MMP-1 protein and mRNA levels. (B) mRNA levels of other MMPs and inflammation-related factors. Relative mRNA levels of MMP-1, MMP-3, IL-1β, IL-6, and IL-8 in UVB-injured HaCaT cells were calculated using qPCR, with normalization to GAPDH expression. Data are presented as means ± SDs (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001 compared with the normal control (NC) group.