Table 7.

Studies without the inclusion criteria.

Reference	Change CoQ10 Total				Measured Parameters and Effects of CoQ10
	Tissue	Plasma Pre ➝ Post (μg/mL)	Plasma Pre ➝ Post (μmol/mol Chol)	Muscle Pre ➝ Post (nmol/g Protein)	Inflammatory Pattern	Antioxidant Pattern	Physical Performance	Sport Performance	Muscle Injury	Other
Drobnic et al. (2020)	Plasma ↑ Muscle ↑	1.11 ➝ 2.34	212 ➝ 476	245 ➝ 299nmol/g protein	IL-6, IL-8, IL-10, MCP-1, TNFa ↓	MDA ↓, TAC ↑ after exercise	Lactate and fatigue perception ↑,
Emami et al. (2018)	Plasma ↑	≃0.8 ➝ ≃2.5				TAC ↑, LPO ↓,			LDH, CK-MB, Mb, Troponin I ↓
Fiorella et al. (1991)	Plasma ↑ Thrombocites↑	0.6 ➝ 1.4 37.5➝61.8					LA, UA, Ammonia ↔	Running distance and time to exhaustion ↑,	CK, LDH ↓,
García-Verazaluce et al. (2015)	-				IL6 ↓					Costisol ↓
Geiss et al. (2004)	Plasma ↑	0.6 ➝ 1.7					Power output ↑
Gökbel et al. (2010)	-						Peak Power ↔, Mean Power ↑, Fatigue Index ↔
Gökbel et al. (2016)	Plasma ↑	1.3 ➝ 3.0				MDA ↓, GPX↓, SOD ↔, after exercise (NS)
Guerra et al. (1987)	Plasma ↑	Ns					VO2max ↑	Possible better race time
Gül et al. (2011)	-					MDA ↓, NO, XO, SOD, GPx ↔, UA ↑
Kaikkonen et al. (1998)	Plasma ↑	1.96 ➝ 2.03				GSH, UA, LDLox, TRAP ↔
Laaksonen et al. (1995)	Plasma ↑ Muscle ↑	0.9 ➝ 2.0		118 ➝ 128 nmol/g protein		MDA ↔	VO2max ↔, Time to exhaustion
	Plasma ↑ Muscle ↔	1.31 ➝ 3.5		92 ➝ 78 nmol/g protein
Leelarungrayub et al. (2010)	Plasma ↑	1.1 ➝ 2.3				MDA, NO ↓, TAC, SOD ↔, GSH ↑	Increase time to fatigue	No better 800 m swimming time
Malm et al. (1996)	-								CK ↑
Malm et al. (1997)	-					ROS ↑	VO2max ↔, Max power ↔
Mizuno et al. (2008)	Plasma ↑	100 mg. 0.5 ➝ 2.0 300 mg. 0.5 ➝ 3.3					Perception of fatigue ↓, Perception of recovery, Max velocity ↑
Nielsen et al. (1999)	Plasma ↑	0.9 ➝ 1.8					VO2max ↔			Muscle metabolism ↔

CoQ10/Chol: CoQ10 in relation to cholesterol level; pre/post: previous and post supplementation; ➝: Concentration change; Ns: No specified, Phys. Physical; Perf: Performance; ↔ similar response to placebo or previous supplementation, ↑ Higher response to the presupplementation phase, ↓ Lower response to the presupplementation phase, NS: Non statistical significance. MDA malondyaldehide, TAC total antioxidant capacity, LPO lipid peroxidation, LDH lactate dehydrogenase, CK-MB miocardic creatinquinase, Mb myoglobin, LA lactic acid, UA uric acid, CK creatinquinase, SOD superoxide dismutase, NO nitric oxide.