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. 2022 Apr 26;23(9):4751. doi: 10.3390/ijms23094751

Figure 3.

Figure 3

Regulation of SOST through the estrogen receptor (ER) pathway. Fluid flow shear stress (FFSS) and estradiol (E2) binding to ERβ suppresses ERα binding to the regulatory motif of SOST resulting in SOST down-regulation. Estradiol binding to the ERs triggers the extracellular signal-regulated kinase (ERK) and Wnt/β-catenin, which suppress SOST expression. The ERα ligand independently maintains basal SOST expression and Erβ inhibition prevents down-regulation of SOST. SOST downregulation = black arrow down; SOST upregulation = black arrow up. Created with BioRender.com, accessed on 15 February 2022.