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Interaction between sclerostin and the low-density lipoprotein receptor-related protein 6 (LRP6). Loop 2 of sclerostin binds to the E1 ectodomain of LRP6, while a part of the C-terminal arm interacts with the E2 ectodomain. Image created in the Research Collaboratory for Structural Bioinformatics—Protein Data Bank with the Mol* Viewer [64], based on the crystal structure LRP6 E1-E2-SOST complex, PDB-ID: 6L6R [63].
