Table 3.

PERMANOVA p values of Demographic and Clinical Factors.

Sample	Bile					Stool
	UniFrac	WUniFrac	GUniFrac	Bray-Curtis	Omnibus	UniFrac	WUniFrac	GUniFrac	Bray-Curtis	Omnibus
Diagnosis *	0.154	0.414	0.409	0.201	0.347	0.18	0.494	0.339	0.287	0.309
Gender	0.01	0.334	0.107	0.728	0.026	0.869	0.9	0.886	0.814	0.963
Age	0.183	0.154	0.123	0.261	0.291	0.052	0.087	0.075	0.195	0.09
BMI	0.581	0.759	0.866	0.671	0.865	0.509	0.206	0.304	0.507	0.338
IBD	0.555	0.305	0.298	0.046	0.117	0.001	0.035	0.021	0.015	0.001
Cholelithiasis	0.254	0.057	0.053	0.147	0.13	0.903	0.722	0.812	0.344	0.517
Hypertension	0.578	0.24	0.246	0.135	0.312	0.636	0.278	0.261	0.400	0.415
Hypercholesterolemia	0.569	0.81	0.796	0.770	0.861	0.995	0.896	0.928	0.850	0.975
Diabetes mellitus	0.840	0.42	0.629	0.716	0.738	0.455	0.804	0.778	0.708	0.667
Ileal Pouch	0.127	0.015	0.011	0.017	0.029	0.001	0.001	0.001	0.001	0.001
Ileostomy	0.213	0.274	0.279	0.421	0.435	0.001	0.001	0.001	0.001	0.001
Cholecystectomy	0.192	0.031	0.03	0.352	0.076	0.918	0.615	0.704	0.226	0.36
Chemotherapy	0.223	0.043	0.044	0.105	0.116	0.161	0.256	0.132	0.051	0.085
Radiotherapy	0.095	0.36	0.303	0.304	0.231	0.406	0.575	0.429	0.189	0.301
Antibiotics use	0.017	0.165	0.05	0.311	0.045	0.002	0.019	0.005	0.007	0.004
Steroid intake	0.689	0.61	0.596	0.281	0.565	0.074	0.429	0.279	0.374	0.125
Immunosuppressant intake	0.582	0.298	0.332	0.06	0.151	0.278	0.35	0.349	0.574	0.438
Stent placement	0.037	0.18	0.078	0.001	0.001	0.463	0.197	0.289	0.335	0.335

UniFrac, unweighted UniFrac distance; WUniFrac, weighted UniFrac distance; GUniFrac, generalized UniFrac distance; Raw p values are presented. *, Diagnosis was a comparison between PSC and CCA wo PSC. Last columns in the Bile and Stool were results of PERMANOVA-based omnibus test [13].