TABLE 2.

Sub-clusters that were found to be associated with significant (p < 0.05) changes in brain activity between both interventions before multiplicity correction, during the EAT paradigm.

MNI coordinates of peak (x y z)	Cluster size [mm3]	ME − MS in probiotic − placebo p-value*	ME − MS in probiotic − placebo effect size	Anatomical region
6 66 6	2,673	0.007	7.110	Medial area 10
48 45 −15	378	0.038	3.451	Orbital gyrus, orbital area 12/47
42 27 −9	1,188	0.041	1.722	Lateral area 12/47

*After correction for multiple testing using Bonferroni, the changes in activation in all sub-clusters (p > 0.05/55) and the predefined ROIs (p > 0.05/10) did not remain statistically significant, nor after FDR correction. EAT, emotional attention task; FDR, false discovery rate; ME, match emotions; MNI, Montreal Neurological Institute; MS, match shapes; ROI, region of interest. Two of these sub-clusters covered predefined ROIs (italic).