Table 2.

Overall toxicities associated with neoadjuvant treatment.

Adverse effect	NACT (n=37)	NACRT (n=38)	P
All grades, No. (%)
Nausea	25 (67.6)	27 (71.1)	0.805
Vomiting	15 (40.5)	16 (42.1)	0.998
Anorexia	23 (62.2)	34(89.5)	0.007
Fatigue	5 (13.5)	21 (55.3)	<0.001
Gastritis	2 (5.4)	14 (36.8)	0.001
Radiation esophagitis	/	14 (36.8)	/
Hand-foot syndrome	5 (13.5)	2 (5.3)	0.262
Leukopenia	21 (56.8)	25 (65.8)	0.482
Neutropenia	24 (64.9)	11 (29.0)	0.003
Anemia	9 (24.3)	6 (15.8)	0.399
Thrombocytopenia	18 (48.6)	2(5.3)	<0.001
ALT/AST elevation	5 (13.5)	0	0.025
Grade 3, No. (%)
Nausea	1 (2.7)	2 (5.3)	0.997
Anorexia	1 (2.7)	2 (5.3)	0.997
Fatigue	1 (2.7)	1 (2.6)	0.999
Gastritis	0	2 (5.3)	0.493
Radiation esophagitis	/	3 (7.9)	/
Leukopenia	0	3 (7.9)	0.240