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Circadian Orchestration of Anti- and Pro-Growth Mechanisms in the Heart. As highlighted in the figure, the heart is primed for growth at the awake-to-sleep transition, through coordinated alignment of mechanisms promoting protein synthesis at this time (green shaded area). Conversely, the cardiac growth response is greatly hindered in the middle of the awake period, due to elevated PER2, p-eIF2α, and AMPK at this time (red shaded area).
