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. Author manuscript; available in PMC: 2022 May 13.
Published in final edited form as: Gynecol Oncol. 2021 Nov 26;164(1):170–180. doi: 10.1016/j.ygyno.2021.09.026

Fig. 3. DKN-01 up-regulates expression of multiple genes that stimulate HLA in a carcinosarcoma patient-derived xenograft.

Fig. 3.

(A.) Schematic of treatment with vehicle or DKN-01 monotherapy (n = 8 per treatment arm). (B.) RNAseq results demonstrate increased gene expression based on Z-score fold change ≥2 and p-value <0.05 (C.) IL-1 and LPS activate NFkB signaling, thereby stimulating HLA-ABC transcription.