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Altered metabolism of 17β-estradiol by nutritional herbs.
| Treatment | Source | Concentration | 2-OHE1:16α-OHE1 Ratio | Relative to E2 Control |
|---|---|---|---|---|
| E2 control | 20 nM | 0.4 ± 0.2 | - | |
| E2 + EG | Leaf/stem | 20 nM + 9.0 µg/mL | 1.9 ± 0.2 | +3.7x |
| E2 + LB | Bark | 20 nM + 0.5 µg/mL | 5.2 ± 0.7 | +12.0x |
| E2 + CO | Fruit | 20 nM + 5.0 µg/mL | 6.8 ± 0.8 | +16.0x |
2-OHE1, 2-hydroxyestrone; 16α-OHE1, 16α-hydroxyestrone; E2, 17β-estradiol; EG, Epimedium grandiflorum; LB, Lycium barbarum; and CO, Cornus officinalis.
