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D-loop migration and unraveling of recombinant intermediates. (A) Homologous search and chain invasion mediated by HOP2–MND1. (B) Telomeric DNA synthesis, promoted by DNA polymerase. (C) D-loop migration, promoted by RAD54. RAD54 may function in coordination with BLM to promote BTR complex-dependent dissolution of recombination intermediates. (D) Intermediates unraveling can also be achieved through SMX complex recruitment, leading to telomere exchange without telomere extension.
