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. 2022 Mar 15;2(4):100111. doi: 10.1016/j.xgen.2022.100111

Figure 3.

Figure 3

Contribution of sequences with non-B DNA motifs toward gene expression

(A) Association between presence of different non-B DNA motifs and expression. Median differences in expression of sequences with and without each non-B DNA motif are shown. Error bars show standard deviation from bootstrapping.

(B) Comparative analysis of sequences with and without G4s and Z-DNA motifs.

(C) Comparative analysis of sequences with and without G4s and Z-DNA motifs controlling for GC content.

(B and C) Statistical significance was calculated with t tests and Bonferroni correction.

(D and E) Relative expression differences between the median expression for sequences with and without non-B DNA motifs and transcription factor binding sites in (D) HepG2 and (E) K562 lentiMPRA.

Statistical significance is estimated with t tests and Bonferroni correction. In (B) and (C), adjusted p values displayed as ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001.