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. 2022 May 2;23(9):5053. doi: 10.3390/ijms23095053

Figure 1.

Figure 1

Biochemical and Structural Features of Ubiquitin & Ubiquitin-like Proteins. (A) Main steps in the substrate modification process by Ub. The β-grasp globular fold structure of Ub is shown in the circle. (B) Examples of structural domains within human type I and type II Ub family members. DUB, de-ubiquitinating enzymes; FAT10, HLA-F-adjacent transcript 10; ISG15, Interferon-stimulated gene 15; NEDD8, Neural precursor cell-expressed developmentally down-regulated gene 8; NUB1, NEDD8 ultimate buster 1; OASL, 2′-5′-oligoadenylate synthetase-like protein; SUMO1, small ubiquitin-like modifier 1; Ub, ubiquitin; UBL, ubiquitin-like domain; UBA, ubiquitin-associated domain. Figure 1A adapted from “ubiquitination”, by BioRender.com (accessed on 1 March 2022). Retrieved from https://app.biorender.com/biorender-templates. Agreement number is OU23V77K75.