Table 4.

Selected DUB small molecule inhibitors reported in neurodegenerative disorders.

Compound ID	Description	Stage
Pimozide	USP1 inhibitor	Phase II trials (https://clinicaltrials.gov/ct2/show/NCT03272503, accessed on 1 March 2022)
IU1, IU1 analogs and derivatives	USP14 inhibitor	Preclinical [64,65,66,67]
Cyanopyrrolidine derivatives, LDN57444	UCHL1 inhibitor	Preclinical [68,69,70]
MTX652, MTX114, MF0094	USP30 inhibitors	Preclinical [71]

Abbreviations: USP, ubiquitin-specific peptidase; UCHL1, ubiquitin carboxyl-terminal hydrolase L1.