Table 5.
Examples of SUMOylation components associated with cancer.
| Gene Name | Deregulation | Caner Type | |
|---|---|---|---|
| Modifier | SUMO1 | ↑ | PM in OC [TCGA] |
| SUMO2 | ↑ | PM in RC, EC, HCC [TCGA] | |
| SUMO3 | ↑ | PM in EC [TCGA] | |
| SUMO E1 | SAE1 | ↑ | PTC [87] PM in HCC, RC, TC [TCGA] |
| SAE2 | ↑ | BC [80], SCLC [81], PM in HCC, RC [TCGA] | |
| SUMO E2 | UBC9 | ↑ | Melanoma [88], PM in TC, HCC [TCGA] |
| SUMO E3 | PIAS1 | ↑ | PTC [87], PCA [89] |
| PIAS2 | ↓ | PTC [87], PM in TC [TCGA] | |
| PIAS3 | ↑ or ↓, Mutation | PM in RC, HCC [TCGA] | |
| PIAS4 | ↑ | PM in EC, PAC [TCGA] | |
| RANBP2 | ↑, Mutation | CRC [90] | |
| deSUMOylase | SENP1 | ↑ | PM in RC, HCC [TCGA] |
| SENP2 | ↓ or ↑, Mutation | PM in EC [TCGA] | |
| SENP3 | ↑ | PM in PAC [TCGA] | |
| SENP5 | ↑ | PM in RC, EC, HCC [TCGA] | |
| SENP6 | ↑ | PM in RC, TC [TCGA] | |
| SENP7 | Long↑; Short varient↓ | BC [91] | |
| ↑ | PM for HNC [TCGA] |
Abbreviations: BC, breast cancer; CRC, colorectal cancer; EC, endometrial cancer; HCC, hepatocellular carcinoma; HNC, Head and neck cancer; PAC, pancreatic cancer; PCA, prostate cancer; RC, renal cancer; TC, Thyroid cancer; SAE, SUMO-activating enzyme; SCC, squamous cell carcinoma; SENP, SUMO-specific proteases; SCLC, small cell lung cancer; OC, ovarian cancer; PIAS, protein inhibitor of activated STAT; PTC, papillary thyroid cancer; UBC9, ubiquitin-conjugating enzyme 9; ↑, Upregulation; ↓, Downregulation. PM, Prognostic marker; TCGA, The Cancer Genome Atlas.