Table 8.
Heart disease related SUMO components.
| Component | Expression | Regulation Pathway | Disease | |
|---|---|---|---|---|
| Modifier | SUMO1 | ↓ | Heart development, cardiac pathology | CHD, HF [134,136] |
| SUMO2/3 conjugates | ↑ | Cardiac pathology | HF [137] | |
| E2 | UBC9 | ↑ | Authophagy | MI, CM [141,142] |
| Deconjugase | SENP1 | ↑ | Mithocondrial function | HF, MI/R [143,144] |
| SENP2 | ↑ | Heart development and function | CHD [134] | |
| SENP5 | ↑ | Mithocondrial function | HF [138] |
Abbreviations: CHD, Congenital heart disease; CM, cardiomyopathy; HF, Heart failure; MI/R, Myocardial Ischemia/Reperfusion injury; MI, Myocardial infarction; ↑, Upregulation; ↓, Downregulation.