Table 4.
Summary of findings based on quality and body of evidence. GRADE.
| Participants (Studies) | Risk of Bias | Inconsistency | Indirectness | Imprecision | Other Considerations | Overall Certainty of Evidence | Impact |
|---|---|---|---|---|---|---|---|
| Probing depth (PPD) | |||||||
| 302 (8 RCTs) |
very serious | serious | not serious | not serious | All plausible residual confounding would reduce the demonstrated effect dose response gradient | +++○ | Six studies have a high risk of bias. In general, studies report different results for PPD |
| Clinical attachment loss (CAL) | |||||||
| 302 (8 RCTs) |
very serious | serious | not serious | not serious | All plausible residual confounding would reduce the demonstrated effect dose response gradient | +++○ | Six studies have a high risk of bias. In general, studies report different results for CAL |
| Gingival inflammation | |||||||
| 302 (8 RCTs) |
very serious | serious | not serious | not serious | All plausible residual confounding would reduce the demonstrated effect dose response gradient | +++○ | Six studies have a high risk of bias. In general, studies report different results for gingival inflammation |
+++○, Moderate.