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. 2022 Apr 26;14(9):2148. doi: 10.3390/cancers14092148

Figure 6.

Figure 6

The presence of two or more ‘high-risk’ spatial features provides independent prognostic information. High-risk feature scores include low intratumoral TILs (scores of 0 or 1), absence of TIL forests (0), presence of immune cold TIL deserts (1), and low peritumoral TIL scores (0 or 1). (a,b) Forest plots of hazard ratios (estimates and 95% CIs) from a univariate Cox proportional hazards model of progression-free interval (PFI) comparing cases with two or more high-risk features (2+) to those with ≤1, as shown in (a) TCGA and (b) UNC CBCS. (c,d) Forest plots of hazard ratios (estimates and 95% CIs) from a multivariate Cox proportional hazards model of progression-free interval (PFI). The dotted line indicates a hazard ratio of 1, where (c) TCGA and (d) UNC CBCS. *** = p < 0.001, ** = p < 0.05, * = p < 0.01.