Table 3.
Comparison of spatial features in the “TIL sensitive” cohorts of TCGA BRCA and UNC-UNC CBCS.
| Feature | TCGA BRCA (n = 430) |
UNC CBCS (n = 481) |
p-Value |
|---|---|---|---|
| Percent Infiltration (%) | |||
| Mean (SD) | 10 (11.9) | 7.89 (12) | 0.00725 |
| Median [Min, Max] | 5.4 [0, 64.2] | 3.3 [0, 88.9] | |
| TIL Class | |||
| Low | 247 (57.4%) | 298 (62.0%) | 0.187 |
| High | 183 (42.6%) | 183 (38.0%) | |
| Intratumoral Strength | |||
| 0 | 4 (0.9%) | 11 (2.3%) | <0.001 |
| 1 | 247 (57.4%) | 282 (58.6%) | |
| 2 | 113 (26.3%) | 64 (13.3%) | |
| 3 | 42 (9.8%) | 34 (7.1%) | |
| Unscored | 24 (5.6%) | 90 (18.7%) | |
| TIL Forests | |||
| Absent | 188 (43.7%) | 260 (54.1%) | <0.001 |
| Present | 218 (50.7%) | 131 (27.2%) | |
| Unscored | 24 (5.6%) | 90 (18.7%) | |
| TIL Deserts | |||
| Absent | 260 (60.5%) | 191 (39.7%) | <0.001 |
| Present | 146 (34.0%) | 200 (41.6%) | |
| Unscored | 24 (5.6%) | 90 (18.7%) | |
| Peritumoral Strength | |||
| 0 | 9 (2.1%) | 3 (0.6%) | 0.365 |
| 1 | 149 (34.7%) | 138 (28.7%) | |
| 2 | 146 (34.0%) | 149 (31.0%) | |
| 3 | 102 (23.7%) | 101 (21.0%) | |
| Unscored | 24 (5.6%) | 90 (18.7%) | |
| Peritumoral Aggregates | |||
| Absent | 87 (20.2%) | 10 (2.1%) | <0.001 |
| Present | 319 (74.2%) | 381 (79.2%) | |
| Unscored | 24 (5.6%) | 90 (18.7%) | |