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. 2022 Apr 20;27(9):2644. doi: 10.3390/molecules27092644

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Knockout of KLF10 mitigated diabetes-induced DKK-1 and phosphorylated β-catenin expression. (A) Western blot analysis was conducted using proteins extracted from the kidney of control or KLF10 knockout mice with or without diabetes (DM). Data are presented as means ± standard deviation obtained from three different mice. ***: p < 0.001 compared with the control group. ###: p < 0.001 compared with the DM group. (B) KLF10 participated in renal fibrogenesis through the regulation of DKK-1 and its downstream pathway.