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. 2022 May 13;46(8):1470–1477. doi: 10.1038/s41366-022-01134-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The values in the path diagram are regression coefficients showing a significant direct effect (P ≤ 0.0001) between the variables. Estimates should be interpreted as one standard deviation increase in birthweight is associated with an increase of 0.21 units in BMI at 7 years. No statistically significant pathways were observed with depression. The estimates for the total, direct and indirect standardized effects of the pathways are presented in Supplementary Table S6. BMI body mass index, CFI comparative fit index, PRS polygenic risk score, RMSEA root square error of approximation, TLI Tucker–Lewis index.