Figure 8.

Summary of the findings of the current study. ROI: reoccurrence of illness index (ROI); M1 macrophage; Th: T helper; IRS: immune-inflammatory responses system; NIT: neuroimmunotoxicity; JAK-STAT: Janus kinases/signal transducer and activator of transcription; NF: nuclear factor; MAPK: mitogen-activated protein kinase; GPCR: G protein-coupled receptors; TNFR: tumor necrosis factor receptor; FGF: fibroblast growth factor; PDGF: platelet-derived growth factor; VEGF: vascular endothelial growth factor; Rap1: Ras-associated protein 1; PI3K-Akt-mTOR: phosphatidylinositol 3 kinase/protein kinase B/mammalian target of rapamycin.