Table 5.

Results of multiple regression analyses with the phenome of affective disorders, the reoccurrence of illness (ROI) index, or immune profiles as dependent variables.

Dependent Variables	Explanatory Variables	β	t	p	F model	df	p	R2
1. Phenome	Model				10.26	4/45	<0.001	0.477
	ACEs	0.622	5.48	<0.001
	Age	−0.185	−1.90	0.118
	Gender	−0.112	−0.99	0.325
	Education	−0.021	−0.19	0.849
2. Phenome	Model				37.21	5/44	<0.001	0.809
	ACEs	0.120	1.34	0.187
	ROI	0.711	8.40	<0.001
	Neuroimmunotoxicity	0.351	3.08	0.004
	Age	−0.162	−2.37	0.022
	CIRS	−0.227	−2.03	0.048
3. Phenome	Model				45.26	4/45	<0.001	0.801
	ROI	0.775	11.05	<0.001
	Neuroimmunotoxicity	0.388	3.47	0.001
	Age	−0.181	−2.67	0.010
	CIRS	−0.240	−2.13	0.038
4. ROI	Model				29.31	1/48	<0.001	0.379
	ACEs	0.616	5.41	<0.001
5.1 M1 macrophage	ACEs	0.384	2.88	0.006	8.30	1/48	0.006	0.147
5.2 Thelper (Th)1	ACEs	0.357	2.65	0.011	7.03	1/48	0.011	0.128
5.3 Th2	ACEs	0.475	3.74	<0.001	13.99	1/48	<0.001	0.226
5.4 Th17	ACEs	0.299	2.17	0.035	4.73	1/48	0.035	0.090
5.5 IRS	ACEs	0.442	3.22	0.002	11.62	1/48	0.001	0.195
5.6 CIRS	ACEs	0.317	2.32	0.025	5.37	1/48	0.025	0.101
5.7 Neuroimmunotoxic	ACEs	0.388	2.92	0.005	8.51	1/48	0.005	0.151
5.8 T cell growth	ACEs	0.452	3.51	<0.001	12.33	1/48	<0.001	0.204
5.9 Growth factors	ACEs	0.425	3.25	0.002	10.58	1/48	0.002	0.181

Phenome: conceptualized as the first principal component (PC) extracted from all symptom domains; ROI: computed as the first PC extracted from number of depressive and total episodes, lifetime number of suicidal attempts, and lifetime suicidal ideation; ACE: adverse childhood experiences computed as sum of mental and physical trauma, mental neglect, domestic violence, family history of mental disease, and loss of a parent; IRS: immune-inflammatory response system; CIRS: compensatory immunoregulatory system. Significant p values are shown in bold.