Table 6.
Top GO and PANTHER biological processes statistically overrepresented in the adverse childhood experiences network (analyzed with OmicsNet and Intact).
| GO Biological Process | Total | Expected | Hits | p | pFDR |
|---|---|---|---|---|---|
| intracellular protein kinase cascade | 1140 | 133 | 285 | 3.37 × 10−39 | 2.76 × 10−36 |
| regulation of I−kappaB kinase/NF−kappaB cascade | 210 | 24.7 | 90 | 1.77 × 10−30 | 7.25 × 10−28 |
| I−kappaB kinase/NF−kappaB cascade | 246 | 28.9 | 98 | 5.50 × 10−30 | 1.50 × 10−27 |
| viral reproductive process | 597 | 70.1 | 169 | 1.91 × 10−29 | 3.92 × 10−27 |
| positive regulation of signal transduction | 998 | 117 | 233 | 7.30 × 10−27 | 1.20 × 10−24 |
| interaction with host | 426 | 50 | 131 | 1.21 × 10−26 | 1.66 × 10−24 |
| regulation of cellular protein metabolic process | 1560 | 183 | 319 | 4.22 × 10−26 | 4.95 × 10−24 |
| regulation of protein modification process | 1250 | 147 | 266 | 3.03 × 10−24 | 3.11 × 10−22 |
| positive regulation of I−kappaB kinase/NF−kappaB cascade | 150 | 17.6 | 66 | 1.93 × 10−23 | 1.76 × 10−21 |
| positive regulation of cellular protein metabolic process | 968 | 114 | 218 | 6.06 × 10−23 | 4.97 ×10−21 |
| positive regulation of protein modification process | 867 | 102 | 201 | 9.54 × 10−23 | 7.11 ×10−21 |
| regulation of protein metabolic process | 1820 | 214 | 347 | 1.81 ×10−22 | 1.18 ×10−20 |
| positive regulation of response to stimulus | 1550 | 182 | 307 | 1.86 ×10−22 | 1.18 ×10−20 |
| viral reproduction | 803 | 94.3 | 189 | 3.39 ×10−22 | 1.90 ×10−20 |
| regulation of MAPK cascade | 559 | 65.6 | 147 | 3.48 ×10−22 | 1.90 ×10−20 |
| PANTHER Biological Process | Total | Expected | Hits | P | pFDR |
| Viral process | 448 | 52 | 150 | 6.09 × 10−36 | 1.18 × 10−33 |
| Negative regulation of apoptotic process | 577 | 67 | 160 | 1.34 × 10−27 | 1.30 × 10−25 |
| Apoptotic process | 699 | 81.2 | 163 | 1.84 × 10−19 | 1.19 × 10−17 |
| Protein phosphorylation | 627 | 72.8 | 140 | 3.93 × 10−15 | 1.91 × 10−13 |
| Immune response | 387 | 44.9 | 96 | 1.61 × 10−13 | 6.24 × 10−12 |
| Rhythmic process | 124 | 14.4 | 42 | 4.77 ×10−11 | 1.54 × 10−09 |
| Angiogenesis | 252 | 29.3 | 61 | 1.27 ×10−08 | 3.53 × 10−07 |
| Cell−cell signaling | 232 | 26.9 | 57 | 2.18 ×10−08 | 5.28 × 10−07 |
| Circadian rhythm | 90 | 10.5 | 27 | 2.07 ×10−06 | 4.47 ×10−05 |
| Cell cycle | 647 | 75.1 | 111 | 1.16 ×10−05 | 0.000224 |
| Translation | 315 | 36.6 | 62 | 1.85 ×10−05 | 0.000326 |
| Cell proliferation | 386 | 44.8 | 72 | 2.73 ×10−05 | 0.000441 |
| Protein folding | 157 | 18.2 | 36 | 4.21 ×10−05 | 0.000628 |
| Protein folding | 157 | 17.8 | 35 | 5.72 ×10−05 | 0.000925 |
FDR: False Discovery Rate.