Table 7.

KEGG pathway classifications of the differently expressed proteins of adverse childhood experiences (results of enrichment analysis using STRING).

Term ID all DEPs	Kegg Pathways	Observed	Background	Strength	FDR
hsa04060	Cytokine−cytokine receptor interaction	34	282	1.56	1.29 × 10−41
hsa04061	Viral protein interaction with cytokine and cytokine receptor	20	96	1.8	1.84 × 10−27
hsa05200	Pathways in cancer	29	517	1.23	4.06 × 10−26
hsa04630	JAK−STAT signaling pathway	20	160	1.58	9.98 × 10−24
hsa05163	Human cytomegalovirus infection	20	218	1.44	2.47 × 10−21
hsa04657	IL−17 signaling pathway	16	92	1.72	6.43 × 10−21
hsa04668	TNF signaling pathway	16	112	1.63	9.65 × 10−20
hsa04151	−Akt signaling pathway	20	350	1.24	1.05 × 10−17
hsa04659	Th17 cell differentiation	14	101	1.62	4.40 × 10−17
hsa05162	Measles	15	138	1.51	5.89 × 10−17
hsa04010	MAPK signaling pathway	18	288	1.27	1.41 × 10−16
hsa04061	Viral protein interaction with cytokine and cytokine receptor	22	96	1.84	2.86 × 10−31
Term ID Cluster 2	Kegg Pathways	Observed	Background	Strength	FDR
hsa04015	Rap1 signaling pathway	9	202	1.76	2.63 × 10−12
hsa04014	Ras signaling pathway	9	226	1.72	3.50 × 10−12
hsa04010	MAPK signaling pathway	9	288	1.61	1.95 × 10−11
hsa05205	Proteoglycans in cancer	8	196	1.73	6.14 × 10−11
hsa04151	−Akt signaling pathway	9	350	1.53	6.47 × 10−11
hsa01521	EGFR tyrosine kinase inhibitor resistance	6	78	2	1.41 × 10−09
hsa05200	Pathways in cancer	8	517	1.31	6.63 × 10−08
hsa05418	Fluid shear stress and atherosclerosis	5	130	1.7	1.73 × 10−06
hsa05230	Central carbon metabolism in cancer	4	69	1.88	8.78 × 10−06
hsa04510	Focal adhesion	5	198	1.52	1.06 × 10−05
hsa04810	Regulation of actin cytoskeleton	5	209	1.49	1.25 × 10−05
Term ID Cluster 2	GO Biological Processes	Observed	Background	Strength	FDR
GO:0001525	Angiogenesis	12	315	1.7	2.15 × 10−15
GO:0001936	Regulation of endothelial cell proliferation	9	134	1.94	4.05 × 10−13
GO:0001938	Positive regulation of endothelial cell proliferation	8	94	2.05	3.65 × 10−12
GO:0010595	Positive regulation of endothelial cell migration	8	103	2.01	6.16 × 10−12
GO:0050679	Positive regulation of epithelial cell proliferation	9	192	1.79	6.16 × 10−12
GO:0007169	Transmembrane receptor protein tyrosine kinase signaling pathway	11	518	1.44	6.18 × 10−12
GO:0050678	Regulation of epithelial cell proliferation	10	339	1.59	7.25 × 10−12
GO:0038084	Vascular endothelial growth factor signaling pathway	6	20	2.59	1.25 × 10−11
GO:0008284	Positive regulation of cell population proliferation	12	919	1.23	3.76 × 10−11
GO:0071363	Cellular response to growth factor stimulus	10	494	1.42	1.75 × 10−10

KEGG: Kyoto Encyclopedia of Genes and Genomes; ID: Identification; FDR: False Discovery Rate; DEP: differentially expressed proteins.