Table 8.
Results of Molecular Complex Detection (MCODE) analysis performed on all differentially expressed proteins (DEPs) and the growth factor cluster of adverse childhood experiences.
| MCODE Components | ID | Annotations | Log10 (p) Value |
|---|---|---|---|
| All DEPs, MCODE1 | Hsa 04060 | Cytokine-cytokine interaction | −55.7 |
| GO:0071345 | Cytokine-mediated signaling pathway | −50.7 | |
| GO:0071345 | Cellular response to cytokine stimulus | −42.8 | |
| All DEPs, MCODE2 | CORUM:5531 | Tumor necrosis factor receptor 1 signaling complex | −11.0 |
| Hsa 04010 | MAPK signaling pathway | −10.0 | |
| CORUM:6347 | TNF-R1 signaling complex | −9.6 | |
| DEPs cluster 2, MCODE1 | GO:0071363 | Cellular response to growth factor stimulus | −39.8 |
| GO:0070848 | Response to growth factor | −39.1 | |
| GO:0007167 | Enzyme-linked receptor protein signaling pathway | −36.7 | |
| DEPs cluster 2, MCODE2 | GO:0001666 | Response to hypoxia | −11.8 |
| GO:0036293 | Response to decreased oxygen levels | −11.7 | |
| GO:0071456 | Cellular response to hypoxia | −11.6 |
Analyses are performed on all DEPs or on the growth factor DEPs (cluster2); ID: Identification; MAPK: mitogen-activated protein kinase; TNF-R: tumor necrosis factor receptor.