Table 9.

Results of inBio Discover annotation analysis with disease ontology annotations of diseases (DOID) performed on the upregulated differentially expressed proteins (DEPs) of adverse childhood experiences.

Term ID all DEPs	DOID Annotations	Size	Overlap	Enrichment	FDR
DOID:0060032	Autoimmune disease of musculoskeletal system	645	91/342	8.25	1.4 × 10−57
DOID:848	Arthritis	481	79/342	9.60	7.9 × 10−55
DOID: 3342	Bone inflammation disease	501	80/342	9.34	1.5 × 10−54
DOID:2914	Immune system disease	1.9 k	139/342	4.28	4.5 × 10−54
DOID:0050589	Inflammatory bowel disease	306	66/342	12.61	1.3 × 10−53
DOID:7148	Rheumatoid arthritis	313	65/342	12.14	1.1 × 10−51
DOID:612	Primary immunodeficiency disease	1.3 k	115/342	5.06	7.4 × 10−51
DOID:417	Autoimmune disease	1.1 k	104/342	5.70	1.9 × 10−50
DOID:65	Connective tissue disease	1.8 k	128/342	4.06	1.6 × 10−46
DOID:8893	Psoriasis	189	50/342	15.47	2.5 × 10−45
Term ID all DEPs	Custom Term Annotations	Size	Overlap	Enrichment	FDR p
DOID: 3213	Demyelinating disease	218	42/342	11.27	5.8 × 10−32
DOID:1936	Atherosclerosis	352	34/342	5.65	3.1 × 10−16
DOID: 936	Brain Disease	1.5 k	59/342	2.29	1.5 × 10−9
WP 1455	Serotonin transported activity	11	3/342	15.95	7.4 × 10−4
GO:1901215	Negative regulation of neuron death	65	5/342	4.50	5.1 × 10−3
GO:1903978	Regulation of microglial cell activation	6	2/342	19.49	4.2 × 10−3

Term ID: term identification; FDR: false discovery rate.