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. 2022 Apr 27;11(9):1475. doi: 10.3390/cells11091475
4-HNE 4-hydroxynonenal
ASMase acid sphingomyelinase
ADH alcohol dehydrogenase
AH alcoholic hepatitis
AIM2 absent in melanoma 2
ALD alcoholic liver disease
ALDH acetaldehyde dehydrogenase
AMPK 5′-AMP-activated protein kinase
ASC adaptor apoptosis speck protein
ASH alcoholic steatohepatitis
ATP adenosine triphosphate
CAT catalase
CerSs ceramide synthase
CYP2E1 cytochrome P450 2E1
DAG diacylglycerol
DAMPS danger-associated molecular patterns
ER endoplasmic reticulum
FA fatty acid
GSDMD gasdermin D
GSH glutathione
GSH-Px glutathione peroxidase
GSSG-Rx glutathione reductase
HCC hepatocellular carcinoma
HSC hepatic stellate cells
IL-18 interleukin-18
IL-1β interleukin-1β
IL-6 interleukin-6
IR insulin resistance
KC Kupffer cells
LPS lipopolysaccharide
MAFLD metabolic dysfunction-associated fatty liver disease
MAM mitochondria-associated membranes
MCD methionine/choline-deficient diet
MDA malondialdehyde
mGSH mitochondrial glutathione
miRNAs microRNAs
MMP mitochondria membrane potential
mt-DNA mitochondrial DNA
mtROS mitochondrial ROS
NADH/NAD+ oxidized and reduced nicotinamide adenine dinucleotide ratio
NAFL nonalcoholic fatty liver
NAFLD nonalcoholic fatty liver disease
NASH nonalcoholic steatohepatitis
NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells
NLRC4 nucleotide-binding oligomerization domain-like receptors CARD domain-containing protein 4
NLRP3 nucleotide-binding oligomerization domain-like receptor protein 3
ox-mtDNA oxidized mitochondrial DNA
PAMPS pathogen-associated molecular patterns
PKCδ protein kinase Cδ
PPARα peroxisome proliferator-activated receptor-α
ROS reactive oxidative species
S1P sphingosine-1-phosphate
S1PRs sphingosine 1-phosphate receptors
S1PR4 type 4 sphingosine-1-phosphate receptor
SM sphingomyelin
SMases sphingomyelinases
SMS1 sphingomyelin synthase 1
SOD superoxide dismutase
SQSTM1/p62 sequestosome-1
SREBP1c sterol regulatory element-binding protein 1c
T2DM type 2 diabetes mellitus
TCA tricarboxylic acid cycle
TLR toll-like receptor
TNF-α tumor necrosis factor alpha
TXNIP thioredoxin-interacting protein
UPR unfolded protein response
VDAC voltage-dependent anion-selective channel
WD Western diet
WHO World Health Organization