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. Author manuscript; available in PMC: 2022 May 13.
Published in final edited form as: ACS Chem Neurosci. 2020 Jun 19;11(13):1855–1862. doi: 10.1021/acschemneuro.0c00305

Figure 5. Human Neuroimaging of FAAH using [11C]CURB.

Figure 5.

A. Transaxial sections of [11C]CURB-PET at baseline (left) and blocking (right) with oral pre-treatment of a FAAH inhibitor (PF-04457845, 50 μg/kg). B. Transaxial (top) and coronal (bottom) [11C]CURB-PET images in a healthy control showing high uptake in striatum, thalamus and cortical areas (left) compared to a subject meeting criteria for cannabis use disorder scanned after overnight abstinence with visibly lower uptake values in striatum, thalamus and cortical areas (right).