Table 3.
Enrichment in non-coding elements in PBC.
| Set | Regions (n) | Regions § (kb) | DNA Content (Mb) | LncRNAs (n) | CircRNAs (n) | MiRNAs (n) | SEs (n) |
|---|---|---|---|---|---|---|---|
| PBC set | 62 | 150.3 | 9.3 | 22 | 362 | 9 | 351 |
| SD | - | 116.9 | - | - | - | - | - |
| Random sets * | 62.0 | 152.8 | 9.3 | 18.6 | 177.0 | 10.0 | 370.1 |
| SD | - | - | - | 4.6 | 78.0 | 7.2 | 51.4 |
| % ** | - | - | - | 24.5 | 5.1 | 46.5 | 63.6 |
| p value | - | - | - | 0.25 | 0.05 | 0.47 | 0.64 |
The analyses were performed on the PBC-associated loci (upper part) and on 1000 random sets (lower part). § Average length of the genomic regions comprising the SNPs of interest. * For the random sets analysis, the average values calculated on 1000 iterations are indicated. ** % of times in which the same or a larger number of lncRNAs, circRNAs, and miRNAs was obtained in the 1000 iterations as compared to the PBC dataset. p values were calculated as described [73]; significant p value is indicated in bold. CircRNA, circular RNA; lncRNA, long non-coding RNA; miRNA, microRNA; n, number; SD, standard deviation; SE, super enhancer.